Molecular structure of interleukin 6 receptor.

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Molecular and cellular biology of interleukin-6 and its receptor.

Interleukin-6 (IL-6) is a member of the family of cytokines collectively termed "the interleukin-6 type cytokines." Among its many functions, IL-6 plays an active role in immunology, bone metabolism, reproduction, arthritis, neoplasia, and aging. IL-6 expression is regulated by a variety of factors, including steroidal hormones, at both the transcriptional and post-transcriptional levels. IL-6 ...

متن کامل

53 . Molecular Structure o f Interleukin 6 Receptort '

Interleukin 6 (IL-6/BSF-2) is a multifunctional cytokine produced by both lymphoid and nonlymphoid cells.l) It is established that IL-6 has many biological functions, which include growth and differentiation activities on B cells,l)-5) T cells, 6)-8) myeloma-plasmacytomas,0)-10) hepatocytes,11 '12) hematopoietic stem cells,13> and nerve cells.14> To elucidate how one cytokine can mediate multip...

متن کامل

The Hepatic Interleukin-6 Receptor

Recombinant human ‘2SI-interleukin-6 (IL-6) was cross-linked with the homobifunctional reagent disuccinimidyl suberate to human hepatoma cells (HepG2). Three recombinant human ’261-IL-6-containing complexes of apparent molecular masses of 100, 120, and 200 kDa were immunoprecipitated with specific antibodies to human IL-6 or to the 80-kDa IL-6 receptor subunit. We show by immunoprecipitation, p...

متن کامل

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

We have probed for the presence of interleukin 6 (IL6) receptors in prostatic carcinoma cell lines (LNCaP, DU 145, and PC3) by examining their sensitivity to the cytotoxic effects of a chimeric toxin composed of IL6 and Pseudomonas exotoxin (PE). All three cell lines were killed by IL6-PE66(4)Glu, a version of IL6-PE in which the binding domain of native PE has been mutated to debilitate PE bin...

متن کامل

Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms (SNPs) in 1,184 African Americans from the Health, Aging and Body Composition (Health ABC) Study. Using admixture mapping, we found a significant association of interleukin 6 soluble receptor (IL-6 SR) w...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Proceedings of the Japan Academy, Series B

سال: 1988

ISSN: 0386-2208,1349-2896

DOI: 10.2183/pjab.64.209